Research
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Highlighted
Control of contextual memory through interneuronal α5-GABAA receptors
PNAS Nexus
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11 Apr 2023
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10.1093/pnasnexus/pgad065
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2024
Association of preoperative to postoperative change in cerebrospinal fluid fibrinogen with postoperative delirium
BJA Open
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01 Dec 2024
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doi:10.1016/j.bjao.2024.100349
2023
Subanaesthetic doses of ketamine reduce but do not eliminate predictive coding responses: implications for mechanisms of sensory disconnection
British Journal of Anaesthesia
·
01 Oct 2023
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doi:10.1016/j.bja.2023.06.044
Resolution of elevated interleukin-6 after surgery is associated with return of normal cognitive function
British Journal of Anaesthesia
·
01 Oct 2023
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doi:10.1016/j.bja.2023.05.023
Prospective analysis of plasma amyloid beta and postoperative delirium in the Interventions for Postoperative Delirium: Biomarker-3 study
British Journal of Anaesthesia
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01 May 2023
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doi:10.1016/j.bja.2023.01.020
Plasma HMGB1 levels in postoperative delirium
British Journal of Anaesthesia
·
01 May 2023
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doi:10.1016/j.bja.2023.02.002
Control of contextual memory through interneuronal α5-GABAA receptors
PNAS Nexus
·
11 Apr 2023
·
10.1093/pnasnexus/pgad065
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.
Changes in Memory, Sedation, and Receptor Kinetics Imparted by the β2-N265M and β3-N265M GABAA Receptor Point Mutations
International Journal of Molecular Sciences
·
15 Mar 2023
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doi:10.3390/ijms24065637
Sevoflurane dose and postoperative delirium: a prospective cohort analysis
British Journal of Anaesthesia
·
01 Feb 2023
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doi:10.1016/j.bja.2022.08.022
2022
Dose-dependent suppression of hippocampal contextual memory formation, place cells, and spatial engrams by the NMDAR antagonist (R)-CPP
Neuropharmacology
·
01 Nov 2022
·
doi:10.1016/j.neuropharm.2022.109215
Propofol Reverses Surgery-Induced Neuroinflammation and Cognitive Impairment in Aged Mice via α5-GABAAReceptors
Cold Spring Harbor Laboratory
·
28 Oct 2022
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doi:10.1101/2022.10.26.513964
Postoperative delirium and changes in the blood–brain barrier, neuroinflammation, and cerebrospinal fluid lactate: a prospective cohort study
British Journal of Anaesthesia
·
01 Aug 2022
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doi:10.1016/j.bja.2022.01.005
Dose-dependent suppression of hippocampal contextual memory formation, place cells, and spatial engrams by the NMDAR antagonist (R)-CPP
Cold Spring Harbor Laboratory
·
16 Jun 2022
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doi:10.1101/2022.06.13.495957
Distinct EEG signatures differentiate unconsciousness and disconnection during anaesthesia and sleep
British Journal of Anaesthesia
·
01 Jun 2022
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doi:10.1016/j.bja.2022.01.010
Role of interleukin-18 in postoperative delirium: an exploratory analysis
British Journal of Anaesthesia
·
01 Mar 2022
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doi:10.1016/j.bja.2021.12.037
Amyloid deposition on positron emission tomography correlates with severity of perioperative delirium: a case-control pilot study
British Journal of Anaesthesia
·
01 Mar 2022
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doi:10.1016/j.bja.2021.12.014
CPP impairs contextual learning at concentrations below those that block pyramidal neuron NMDARs and LTP in the CA1 region of the hippocampus
Neuropharmacology
·
01 Jan 2022
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doi:10.1016/j.neuropharm.2021.108846
2021
Impact of postoperative delirium on days alive and at home after surgery: a prospective cohort study
British Journal of Anaesthesia
·
01 Dec 2021
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doi:10.1016/j.bja.2021.08.027
Hippocampal β2-GABAA receptors mediate LTP suppression by etomidate and contribute to long-lasting feedback but not feedforward inhibition of pyramidal neurons
Journal of Neurophysiology
·
01 Oct 2021
·
doi:10.1152/jn.00303.2021
Relationships between preoperative cortical thickness, postoperative electroencephalogram slowing, and postoperative delirium
British Journal of Anaesthesia
·
01 Aug 2021
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doi:10.1016/j.bja.2021.02.028
Physiological Characterization and Transcriptomic Properties of GnRH Neurons Derived From Human Stem Cells
Endocrinology
·
14 Jun 2021
·
doi:10.1210/endocr/bqab120
Postoperative troponin increases after noncardiac surgery are associated with raised neurofilament light: a prospective observational cohort study
British Journal of Anaesthesia
·
01 Apr 2021
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doi:10.1016/j.bja.2020.10.012
Association between plasma tau and postoperative delirium incidence and severity: a prospective observational study
British Journal of Anaesthesia
·
01 Feb 2021
·
doi:10.1016/j.bja.2020.08.061
2020
Isoflurane Potentiation of GABAA Receptors Is Reduced but Not Eliminated by the β3(N265M) Mutation
International Journal of Molecular Sciences
·
15 Dec 2020
·
doi:10.3390/ijms21249534
2019
Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways
Nature Communications
·
06 Aug 2019
·
doi:10.1038/s41467-019-11459-4
Wake Up, Neurons! Astrocytes Calling
Anesthesiology
·
01 Mar 2019
·
doi:10.1097/ALN.0000000000002589
2018
Doc2-mediated superpriming supports synaptic augmentation
Proceedings of the National Academy of Sciences
·
29 May 2018
·
doi:10.1073/pnas.1802104115
2017
Flow characterization and patch clamp dose responses using jet microfluidics in a tubeless microfluidic device.
Journal of neuroscience methods
·
23 Aug 2017
·
pmid:28842193
2016
Contrasting Effects of the γ-Aminobutyric Acid Type A Receptor β3 Subunit N265M Mutation on Loss of Righting Reflexes Induced by Etomidate and the Novel Anesthetic Barbiturate R-mTFD-MPAB.
Anesthesia and analgesia
·
01 Nov 2016
·
pmid:27331778
Lipid-free Fluoropolymer-based Propofol Emulsions and Lipid Reversal of Propofol Anesthesia in Rats.
Anesthesiology
·
01 Jun 2016
·
pmid:26938988
2015
Tonic Inhibitory Control of Dentate Gyrus Granule Cells by α5-Containing GABAAReceptors Reduces Memory Interference
The Journal of Neuroscience
·
07 Oct 2015
·
doi:10.1523/JNEUROSCI.1370-15.2015
Etomidate Impairs Long-Term Potentiation In Vitro by Targeting α5-Subunit Containing GABAA Receptors on Nonpyramidal Cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience
·
01 Jul 2015
·
pmid:26134653
Etomidate blocks LTP and impairs learning but does not enhance tonic inhibition in mice carrying the N265M point mutation in the beta3 subunit of the GABA(A) receptor.
Neuropharmacology
·
11 Feb 2015
·
pmid:25680234
Spatiotemporal characteristics and pharmacological modulation of multiple gamma oscillations in the CA1 region of the hippocampus.
Frontiers in neural circuits
·
12 Jan 2015
·
pmid:25628540
2014
Enhancement of α5-containing γ-aminobutyric acid type A receptors by the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6) is abolished by the β3(N265M) mutation.
Anesthesia and analgesia
·
01 Dec 2014
·
pmid:25211390
Measurement of NMDA Receptor Antagonist, CPP, in Mouse Plasma and Brain Tissue Following Systematic Administration Using Ion-Pair LCMS/MS.
Analytical methods : advancing methods and applications
·
21 Aug 2014
·
pmid:25663848
A nonequilibrium binary elements-based kinetic model for benzodiazepine regulation of GABAA receptors.
The Journal of general physiology
·
01 Jul 2014
·
pmid:24981228
Midazolam and atropine alter theta oscillations in the hippocampal CA1 region by modulating both the somatic and distal dendritic dipoles.
Hippocampus
·
07 Jun 2014
·
pmid:24862458
2012
Isoflurane enhances both fast and slow synaptic inhibition in the hippocampus at amnestic concentrations.
Anesthesiology
·
01 Apr 2012
·
pmid:22343472
Exceptionally stable fluorous emulsions for the intravenous delivery of volatile general anesthetics.
Anesthesiology
·
01 Mar 2012
·
pmid:22354241
Isoflurane impairs odour discrimination learning in rats: differential effects on short- and long-term memory.
British journal of anaesthesia
·
17 Jan 2012
·
pmid:22258200
2011
Histamine release associated with intravenous delivery of a fluorocarbon-based sevoflurane emulsion in canines.
Journal of pharmaceutical sciences
·
18 Jan 2011
·
pmid:21246564
2010
How we recall (or don't): the hippocampal memory machine and anesthetic amnesia.
Canadian journal of anaesthesia = Journal canadien d'anesthesie
·
18 Dec 2010
·
pmid:21170624
GABA A,slow: causes and consequences.
Trends in neurosciences
·
09 Dec 2010
·
pmid:21145601
Slowing of the hippocampal θ rhythm correlates with anesthetic-induced amnesia.
Anesthesiology
·
01 Dec 2010
·
pmid:21042201
m-Azipropofol (AziPm) a photoactive analogue of the intravenous general anesthetic propofol.
Journal of medicinal chemistry
·
12 Aug 2010
·
pmid:20597506
The short splice variant of the gamma 2 subunit acts as an external modulator of GABA(A) receptor function.
The Journal of neuroscience : the official journal of the Society for Neuroscience
·
07 Apr 2010
·
pmid:20371809
A microfluidic brain slice perfusion chamber for multisite recording using penetrating electrodes.
Journal of neuroscience methods
·
26 Feb 2010
·
pmid:20219536
Breakdown in cortical effective connectivity during midazolam-induced loss of consciousness.
Proceedings of the National Academy of Sciences of the United States of America
·
25 Jan 2010
·
pmid:20133802
2009
Altered GABAA,slow inhibition and network oscillations in mice lacking the GABAA receptor beta3 subunit.
Journal of neurophysiology
·
21 Oct 2009
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pmid:19846622
Amnestic concentrations of etomidate modulate GABAA,slow synaptic inhibition in hippocampus.
Anesthesiology
·
01 Oct 2009
·
pmid:19741493
All Together Now
Anesthesiology
·
01 May 2009
·
doi:10.1097/aln.0b013e31819db946
Identification of a fluorescent general anesthetic, 1-aminoanthracene.
Proceedings of the National Academy of Sciences of the United States of America
·
03 Apr 2009
·
pmid:19346473
Modulation of the Hippocampal θ-Rhythm as a Mechanism for Anesthetic-Induced Amnesia
Contemporary Clinical Neuroscience
·
01 Jan 2009
·
doi:10.1007/978-1-60761-462-3_10
Introduction
Contemporary Clinical Neuroscience
·
01 Jan 2009
·
doi:10.1007/978-1-60761-462-3_1
2008
GABAA receptor alpha5 subunits contribute to GABAA,slow synaptic inhibition in mouse hippocampus.
Journal of neurophysiology
·
10 Dec 2008
·
pmid:19073796
Fluoropolymer-based emulsions for the intravenous delivery of sevoflurane.
Anesthesiology
·
01 Oct 2008
·
pmid:18813044
2007
Muscarinic blockade weakens interaction of gamma with theta rhythms in mouse hippocampus.
The European journal of neuroscience
·
01 Sep 2007
·
pmid:17880398
Amnesic concentrations of the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6, 2N) and isoflurane alter hippocampal theta oscillations in vivo.
Anesthesiology
·
01 Jun 2007
·
pmid:17525592
Functional neural development from human embryonic stem cells: accelerated synaptic activity via astrocyte coculture.
The Journal of neuroscience : the official journal of the Society for Neuroscience
·
21 Mar 2007
·
pmid:17376968
Determination of the EC50 amnesic concentration of etomidate and its diffusion profile in brain tissue: implications for in vitro studies.
Anesthesiology
·
01 Jan 2007
·
pmid:17197853
2006
Active and passive membrane properties and intrinsic kinetics shape synaptic inhibition in hippocampal CA1 pyramidal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
·
16 Aug 2006
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pmid:16914682
An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice.
The Journal of pharmacology and experimental therapeutics
·
28 Jun 2006
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pmid:16807363
2005
Tandem subunits effectively constrain GABAA receptor stoichiometry and recapitulate receptor kinetics but are insensitive to GABAA receptor-associated protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience
·
07 Dec 2005
·
pmid:16339017
Non-immobilizers put to the test: F6 and the GABAA receptor
International Congress Series
·
01 Nov 2005
·
doi:10.1016/j.ics.2005.06.040
The gamma-subunit governs the susceptibility of recombinant gamma-aminobutyric acid type A receptors to block by the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6, 2N).
Anesthesia and analgesia
·
01 Aug 2005
·
pmid:16037152
The differential effects of the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6, 2N) and isoflurane on extrasynaptic gamma-aminobutyric acid A receptors.
Anesthesia and analgesia
·
01 Jun 2005
·
pmid:15920193
Specification of motoneurons from human embryonic stem cells.
Nature biotechnology
·
30 Jan 2005
·
pmid:15685164
Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells.
Stem cells (Dayton, Ohio)
·
01 Jan 2005
·
pmid:15917474
2004
Influence of GABAA receptor gamma2 splice variants on receptor kinetics and isoflurane modulation.
Anesthesiology
·
01 Oct 2004
·
pmid:15448526
Determination of diffusion and partition coefficients of propofol in rat brain tissue: implications for studies of drug action in vitro.
British journal of anaesthesia
·
17 Sep 2004
·
pmid:15377586
Diversity of inhibitory neurotransmission through GABA(A) receptors.
Trends in neurosciences
·
01 Sep 2004
·
pmid:15331240
Effects on synaptic inhibition in the hippocampus do not underlie the amnestic and convulsive properties of the nonimmobilizer 1,2-dichlorohexafluorocyclobutane.
Anesthesiology
·
01 Jul 2004
·
pmid:15220773
Anesthetic effects on glutamatergic neurotransmission: lessons learned from a large synapse.
Anesthesiology
·
01 Mar 2004
·
pmid:15108957
2003
Lidocaine Enhances GαiProtein Function
Anesthesiology
·
01 Nov 2003
·
doi:10.1097/00000542-200311000-00015
Differential uptake of volatile agents into brain tissue in vitro. Measurement and application of a diffusion model to determine concentration profiles in brain slices.
Anesthesiology
·
01 Jul 2003
·
pmid:12826851
Effects of gamma2S subunit incorporation on GABAA receptor macroscopic kinetics.
Neuropharmacology
·
01 Jun 2003
·
pmid:12763093
Isoflurane antagonizes the capacity of flurothyl or 1,2-dichlorohexafluorocyclobutane to impair fear conditioning to context and tone.
Anesthesia and analgesia
·
01 Apr 2003
·
pmid:12651651
2002
Development of GABA(A) receptor-mediated inhibitory postsynaptic currents in hippocampus.
Journal of neurophysiology
·
01 Dec 2002
·
pmid:12466433
2000
Networks of interneurons with fast and slow gamma-aminobutyric acid type A (GABAA) kinetics provide substrate for mixed gamma-theta rhythm.
Proceedings of the National Academy of Sciences of the United States of America
·
05 Jul 2000
·
pmid:10869419
Rapid and direct modulation of GABAA receptors by halothane.
Anesthesiology
·
01 May 2000
·
pmid:10781283
Kinetic differences between synaptic and extrasynaptic GABA(A) receptors in CA1 pyramidal cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience
·
01 Feb 2000
·
pmid:10648698
Interactions between distinct GABA(A) circuits in hippocampus.
Neuron
·
01 Feb 2000
·
pmid:10719898
Effects of halothane on GABA(A) receptor kinetics: evidence for slowed agonist unbinding.
The Journal of neuroscience : the official journal of the Society for Neuroscience
·
01 Feb 2000
·
pmid:10648694
Is anesthesia caused by potentiation of synaptic or intrinsic inhibition? Recent insights into the mechanisms of volatile anesthetics.
Journal of basic and clinical physiology and pharmacology
·
01 Jan 2000
·
pmid:11037765
1999
Barbiturates and the Brain: Disrupting the Delicate Balance
Anesthesiology
·
01 Nov 1999
·
doi:10.1097/00000542-199911000-00007
Dual actions of volatile anesthetics on GABA(A) IPSCs: dissociation of blocking and prolonging effects.
Anesthesiology
·
01 Jan 1999
·
pmid:9915321
1998
Concentration measures of volatile anesthetics in the aqueous phase using calcium sensitive electrodes.
Journal of neuroscience methods
·
01 Jun 1998
·
pmid:9696323
The synaptic basis of GABAA,slow.
The Journal of neuroscience : the official journal of the Society for Neuroscience
·
15 Feb 1998
·
pmid:9454840
1997
GABAA-mediated IPSCs in piriform cortex have fast and slow components with different properties and locations on pyramidal cells.
Journal of neurophysiology
·
01 Nov 1997
·
pmid:9356403
A628 Enflurane reduces IPSC amplitude by a postsynaptic mechanism
Anesthesiology
·
01 Sep 1997
·
doi:10.1097/00000542-199709001-00628
A617 Effect of halothane on GABA sub A receptors studied using rapid application techniques
Anesthesiology
·
01 Sep 1997
·
doi:10.1097/00000542-199709001-00617
1996
Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology.
Proceedings of the National Academy of Sciences of the United States of America
·
25 Jun 1996
·
pmid:8692820
Volatile anaesthetic enhancement of paired-pulse depression investigated in the rat hippocampus in vitro.
The Journal of physiology
·
01 May 1996
·
pmid:8734993
1995
Different mechanisms for use-dependent depression of two GABAA-mediated IPSCs in rat hippocampus.
The Journal of physiology
·
15 Apr 1995
·
pmid:7602535
1993
Mechanisms of intersegmental coordination in leech locomotion
Seminars in Neuroscience
·
01 Feb 1993
·
doi:10.1016/S1044-5765(05)80023-5
Physiological evidence for two distinct GABAA responses in rat hippocampus.
Neuron
·
01 Feb 1993
·
pmid:8382497
1989
Effect of Volatile Anesthetics on Synaptic Transmission in the Rat Hippocampus
Anesthesiology
·
01 Oct 1989
·
doi:10.1097/00000542-198910000-00019
Effect of volatile anesthetics on synaptic transmission in the rat hippocampus.
Anesthesiology
·
01 Oct 1989
·
pmid:2802217
Retrotrapezoid nucleus in the rat.
Neuroscience letters
·
19 Jun 1989
·
pmid:2771161
1988
A model for intersegmental coordination in the leech nerve cord.
Biological cybernetics
·
01 Jan 1988
·
pmid:3382701
1987
Neural mechanisms generating the leech swimming rhythm: swim-initiator neurons excite the network of swim oscillator neurons.
Journal of comparative physiology. A, Sensory, neural, and behavioral physiology
·
01 Aug 1987
·
pmid:3668878
1985
Intersegmental coordination of the leech swimming rhythm. II. Comparison of long and short chains of ganglia.
Journal of neurophysiology
·
01 Dec 1985
·
pmid:4087043
Intersegmental coordination of the leech swimming rhythm. I. Roles of cycle period gradient and coupling strength.
Journal of neurophysiology
·
01 Dec 1985
·
pmid:4087042
1984
Intersegmental coordination of leech swimming: comparison of in situ and isolated nerve cord activity with body wall movement.
Brain research
·
14 May 1984
·
pmid:6733455
1982
Measurement of rCBF by H2 clearance: theoretical analysis of diffusion effects.
Stroke
·
01 Jan 1982
·
pmid:7080129
Web of Science
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